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quinidine n.【化學】奎尼定。

quinin

Mdr1 express product p - glycoprotein was detected by immunocytochemical method and flowcytometry . the cytotoxicity and multidrug resistance reversion effect of tea polyphenol was examined by mtt assay in mcf - 7 and mcf - 7 adr carcinoma cell lines , and compared with pgp inhibitor quinidine . the pgp expression of mcf - 7 adr was strongly positive , the positive rate was 15 % ; the pgp expression of mcf - 7 was negative , the positive rate was 1 . 8 % . ic50 of tea polyphenol to mcf - 7 and mcf - 7 adr is 115 . 2g ml and 207 . 6g ml respectively . ic50 of quinidine to mcf - 7 and mcf - 7 adr is 129 . 8mol l 42 . 1g ml and 94 . 1mol l 30 . 5g ml respectively . tea polyphenol and quinidine changed little toxicity of adriamycin to mcf - 7 , but tea polyphenol and quinidine improved the sensitivity of mcf - 7adr to adriamycin significantly . immunocytochemistry and flow cytometry can detect p - glycoprotein expression level qualitatively and quantitatively . tea polyphenol is not only an anti - tumor agent , but also a multidrug resistant modulator similar as quinidine . tea polyphenol is advantageous for its little toxicity in tumor treatment 用免疫組化法和流式細胞儀對腫瘤細胞系mcf - 7和mcf - 7 adr的p -糖蛋白表達水平進行定性定量研究。用噻唑藍比色法mtt研究茶多酚的細胞毒性及其對耐藥性的逆轉作用,并與pgp抑制劑奎尼定進行了比較。免疫組化法檢測p -糖蛋白表達水平, mcf - 7 adr呈強陽性,而mcf - 7呈陰性流式細胞儀定量檢測結果mcf - 7 adr細胞系細胞陽性率為15 % , mcf - 7細胞系細胞陽性率為1 . 8 % 。

Thus theoretically , weakly acidic drugs ( eg , aspirin ) are more readily absorbed from an acid medium ( stomach ) than are weak bases ( eg , quinidine ) 因此,從理論上講,弱酸性藥物(如阿司匹林)在酸性介質中(胃腔)比弱堿性藥物(如奎寧)更易吸收。

Mechanism of proarrhythmic effect of quinidine 奎尼丁誘發心律失常的機制研究

Sinus rhythm can often be maintained with quinidine . 奎寧丁常可用以維持竇性節律。