N - nociceptive 中文

nociceptive adj.疼痛的，致痛的；有疼痛反映的。

nock
There was much evidence showing that substantia gelatinosa ( sg ) of the spinal dorsal horn plays an important role in nociceptive information transmission from the periphery to central nervous system . thus , the present study firstly investigated the effect of nociceptin on membrane current of spinal dorsal hom substantia gelatinosa ( sg ) neurons by use of the whole - cell patch - clamp technique 故灘究首先應用脊髓薄片膜片鉗全細胞記錄技術觀察了在電壓鉗制下孤啡肽受體的內源性配體nociceptin對脊髓背角sg神經元膜電流的影響作用以及其對脊髓背角興奮性和抑制性突觸傳遞的作用，其次觀察了nand
When examined using some inhibitors with respect to orll receptor , the nociceptin - induced current was depressed in amplitude by nocistatin ( a putative nociceptive precursor product ) and also by compb ( a non - peptidyl orll receptor antagonist ) to a different extent without a change in holding currents of sg neurons Noosoo h口對傳向脊髓背角sg神經元的興奮性和抑制性突觸傳遞的影響在i己錄電極內液中加入gdp書s 、艷離子和tea （主要用于阻斷突觸后的g蛋白和鉀通道的作用）的狀況下， nociceptin誘致的外向電流可以完全被阻斷。
But , so far , there is little study with the relationship between cb and visceral nociceptive stimulation . morphological study of the distribution of cb - immunoreactive neurons involved in modulating visceral nociceptive signal in the related nuclei in brainstem and the projection of those neurons from nts to bst was investigated in the present study 本文主要對cb在大鼠腦干內相關結構特別是與內臟傷害性信息傳遞和調控相關聯核團內的分布，以及參與內臟傷害性信息傳遞的cb樣神經元由孤束核向終紋床核的投射進行了研究。
Using the double - labeled methods of visceral nociceptive stimulation induced by formalin combined with immunocytochemistry , it was observed that the cb positive neurons expressing fos protein distributed in the related nuclei of brainstem in the rat . under microscope it was showed that there were a various numbers of fos / cb double - labeled neurons , besides fos and cb single - labeled neurons , in nts , vlm , lc , lpb and vlpag 第四軍醫大學碩士學位論文給予內臟傷害性刺激并結合免疫組化雙重標記染色，觀察了大鼠腦干相關核團內含cb并表達fos的神經元分布狀況，結果顯示：在nts 、 vlm 、 lc 、 pb和vipag等核團內除下。
According to behavioral studies in adult rats , intrathecal administration of nociceptin , anandamide and win - 55 , 212 ( win - 2 ) ( cannabinoid receptor agonists ) produces an antinoceptive effect in versatile pain models including acute , tonic and chronic pain models ( see mogil & pasternak , 2001 ; pertwee , 2001 for review ) . thus , it could be concluded that nociceptin - orll receptor and anandamide - cannabinoid receptor systems constitute an important part of endogenous antinociceptive system . however , cellular mechanisms underlying the actions of orl1 and cannabinoid receptors on nociceptive information transmission in the spinal cord are still unknown 行為學研究也觀察到鞘內注入nociceptin和大麻受體的激動劑如win55 , 212 - 2 ( win - 2 ) 、 anandamide等均可在多種痛模型上(包括急性痛、持續性痛和慢性痛模型等)產生明顯的抗傷害性作用( seemogil pasternak , 2001 ; pertwee , 2001forreview ) ，由此可見nociceptin ?孤啡肽受體系統和anandamide ?大麻受體系統構成了內源性鎮痛系統的重要組成部分。
Not only the neurons but also the as in the rat brain play a very important role in the process of the peripheral nociceptive stimulation ; ? he newly - found eda may be the functional intercommunication ultrastructure between neurons and as , through which the as could modulate the neurons in the pain signal processing ; @ as might play an active and important role for modulation of pain through a new pathway from the peripheral afferent nerve to the as , then to neurons via electron - dense areas forming the glia - neuron s ignaling network 光、電鏡水平發現as與神經元之間有多種途徑進行信息交流，新發現的eda有可能是神經元與as之間信息交流的結構之一。阻斷as與神經元間信息交流連接后，前者對外周組織4第四軍醫大學博士學位論文損傷所致疼痛的反應不受影響，而后者的反應明顯受到抑制，提示在非病理性疼痛反應中，膠質細胞對神經元具有主動調控作用。
Substantia gelatinosa ( sg ; lamina ii ) of the spinal dorsal horn is the first station of the peripheral nociceptive information , which receives the termination of both non - and thin - myelinated primary afferent fibers and brainstem descending fibers , and plays an important role in peripheral nociceptive information transmission and modulation 脊髓背角層(膠狀質) ，是接受外周傷害性信息傳入的初級門戶，既接受無髓和薄髓初級傳入纖維的投射，也是腦干向脊髓下行投射纖維的終止部位之一，在外周傷害性信息傳遞和整合中發揮重要作用。
The behavioral observation of nociceptive responses were carried out immediately after formalin administration by examining the total time used for licking and biting towards the injected hindpaw by rats , and then , one hour later after formalin injection , rats were killed for immunocytochemical procedures for fos expression in the dorsal horn R ，或mgi叭:的拮抗劑c尸ccoet / mpe尸。以單純注射formalin側背角的fos表達( fli神經元)作為對照，對同一脊髓雙側背角的fl工進行觀察、記數并進行比較和統計學處理。
The selective action of capsaicin on primary afferent fibers that transmit nociceptive information simulates nociceptive stimulation in vivo , therefore , the ne depression of primary afferent terminal neurotransmitter release might be significant on nociceptive modulation at spinal level Caps選擇性地作用于傳遞傷害性信息的初級傳入纖維，模擬了在體傷害性刺激，因此， ne對初級傳人終末遞質釋放的抑制，在脊髓水平的傷害性信息調控過程中可能具有重要意義。
Objective to explore the mechanism of visceral nociceptive sensation of neurons in anterior cingulate gyrus ( acg ) on the cell level and the effect of atropine on visceral nociceptive evoked responses of acg neurons to stimulating contralateral greater splanchnic nerve ( gsn ) 摘要目的觀察阿托品對扣帶回前部神經元內臟痛覺誘發反應的影響，從神經元水平探討扣帶回前部神經元在內臟痛覺感受中的作用及其機制。
By using the bee venom and other models of pain , they screened a novel anti - nociceptive drug with a distinct mechanism from opioids or nsaids ( patent acceptation no . 011 13738 . 7 ) with high potentiality for clinical use （ 2 ）應用新的蜜蜂毒痛模型開展了臨床鎮痛新藥的篩選及其鎮痛機理研究，成功地篩選出一個臨床鎮痛新藥，獲得鎮痛新藥專利受理一項（ no
2 . formalin - induced nociceptive behavioral responses included two phases , and subcutaneous pretreatment of cpccoet or mpep significantly suppressed the tonic responses without effects on the acute nociceptive responses 第i組代謝型谷氨酸受體的拮抗劑cpccoet或mpe尸，可以明顯減弱福爾馬林注射引起的痛行為反應的第二相，而對第一相行為反應無明顯影響。
Recent study has proved that cb occurs in some pathways of transmitting somatic nociceptive information . it is suggested that cb might be involved in processing somatic nociceptive information 近年來的研究觀察到cb存在于軀體傷害性信息傳遞通路中，可能參與軀體傷害性信息在中樞的傳遞過程。
Capsaicin has become a popular tool in the nociceptive study as it can selectively excite non - and thin - myelinated fibers that transmit nociceptive information 辣椒素( capsaicin ， caps )能選擇性地作用于傳遞傷害性信息的無髓和薄髓纖維，是傷害性信息傳遞研究中常用的工具藥。
Peripheral injection of formalin into plantar aspect of hindpaw produced both nociceptive behavioral responses and fos expression in the spinal dorsal horn 上述結果表明: l 、大鼠后腳掌注射福爾馬林可以同時引起大鼠的行為痛反應和脊髓背角的fos蛋白表達。
His review of experimental and clinical studies demonstrated that interactions with brain structures were important for the processing of nociceptive information 他對實驗和臨床研究綜述發現，大腦結構之間的相互作用在傷害性疼痛的處理過程中很重要。
In the pathway of visceral nociceptive impulses ascending from gsn to acg , some neurons might contain acetylcholine , and have m - receptor 在內臟大神經傳導的內臟痛覺沖動到達扣帶回前部神經元的傳入通路中存有膽堿能神經元，并通過m受體起作用。
In addition , cortico - limbic pathways integrated nociceptive input with contextual information and memory to provide cognitive mediation of pain affect 此外，皮質-邊緣通路整合傷害性刺激輸入并使之成為記憶，以起到影響疼痛的認知調停作用。
The results of the present study suggest that cb might be involved in the transmission of visceral nociceptive information from nts to bst 8 。結果提示由nts中繼并向bst傳遞的內臟傷害性信息傳導通路中， cb可能發揮重要作用。

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圖片	移動背景圖固定背景圖重製上傳圖片

nociceptive

nociceptive adj.疼痛的，致痛的；有疼痛反映的。

nock

Peripheral injection of formalin into plantar aspect of hindpaw produced both nociceptive behavioral responses and fos expression in the spinal dorsal horn 上述結果表明: l 、大鼠后腳掌注射福爾馬林可以同時引起大鼠的行為痛反應和脊髓背角的fos蛋白表達。

His review of experimental and clinical studies demonstrated that interactions with brain structures were important for the processing of nociceptive information 他對實驗和臨床研究綜述發現，大腦結構之間的相互作用在傷害性疼痛的處理過程中很重要。

In the pathway of visceral nociceptive impulses ascending from gsn to acg , some neurons might contain acetylcholine , and have m - receptor 在內臟大神經傳導的內臟痛覺沖動到達扣帶回前部神經元的傳入通路中存有膽堿能神經元，并通過m受體起作用。

In addition , cortico - limbic pathways integrated nociceptive input with contextual information and memory to provide cognitive mediation of pain affect 此外，皮質-邊緣通路整合傷害性刺激輸入并使之成為記憶，以起到影響疼痛的認知調停作用。

The results of the present study suggest that cb might be involved in the transmission of visceral nociceptive information from nts to bst 8 。結果提示由nts中繼并向bst傳遞的內臟傷害性信息傳導通路中， cb可能發揮重要作用。