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ngr NGr =New Greek 新希臘語。

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Nogo - 66 receptor , ngr , cloned in 2001 , is a leucine - rich - repeat glycophosphatidylinositol - anchored membrane protein which mediates nogo - 66 inhibition of axonal outgrowth . both the long acidic amino - terminal domain and the nogo - 66 fragment have strong neurite growth inhibitory activity suggest that nogo - a has at least two inhibitory domains . northern blot , in situ hybridization , western blot and immunocytochemistry analyses show that in addition to oligodendrocytes , nogo - a mrna and nogo - a protein are also expressed in neurons in developing and adult brain and spinal cord , nogo - a is also found in peripheral organs such as heart and testis Northernblot 、原位雜交、 westernblot和免疫組化結果證明: nogo amrna和nogo蛋白除了在cns的寡突膠質細胞中表達,還表達于發育階段和成年的腦、脊髓和外周神經節的某些神經元中,在外周組織如睪丸和心臟也有表達; nogoe在cns和pns以及多種外周組織中有廣泛分布; nogo (除表達于腦和心臟外,在骨骼肌中有較高表達。

The expression of nogo - a and ngr in the brain of senile rat 在老年大鼠腦組織中的表達分布

Establishment of an expression vector of ngr - specific sirna 篩選及其表達載體構建