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metrazol n.【藥學】伸戊四唑,五甲烯四氮唑〔一種中樞神經系統刺激...

metre

We have studied pharmacodynamics of valepotriates through observing its effects on the times of spontaneous motion in mice , the sleep time of sodium pentobarbital ( superthreshold doses ) , sleep rate of sodium pentobarbital ( subthreshold doses ) , the number of writhes induced by acetic acid and seizures rate of metrazol . the experiment results proved that valepotriates could significantly decrease the times of spontaneous motion , prolong the sleep time of sodium pentobarbital ( superthreshold doses ) , enhance the sleep rate of sodium pentobarbital ( subthreshold doses ) , reduce the number of writhes induced by acetic acid and reduce the seizures rate of metrazol , so it showed high central inhibition effect , thus offer scientific foundation for its further exploitation and utilization 通過研究蜘蛛香中總纈草素對小鼠自發活動的影響、對戊巴比妥鈉睡眠時間的影響、對戊巴比妥鈉閾下劑量的影響、對小鼠扭體反應的影響、對戊四氮誘發驚厥的影響發現:總顆草素能明顯抑制小鼠的自主活動,顯著延長戊巴比妥鈉致小鼠睡眠時間,明顯提高閾下劑量戊巴比妥鈉小鼠入睡數,對抗戊四氮誘發的小鼠驚厥,顯示出較好的中樞抑制作用,為蜘蛛香的進一步研究開發提供了科學依據。