x
uploads/exotoxin.jpg

exotoxin n.【生物化學】(菌體)外毒素,外泌毒。

exotropia

Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin , diphtheria toxin , shiga toxin and pseudomonas exotoxin ( pe ) . a number of these toxins are transported to trans - golgi network ( tgn ) , and in many cases such transport to the tgn is required for the translocation and cytotoxicity . in deed , 5 % of the ricin endocytosed by cells has been shown to reach the tgn 蓖麻毒素進入細胞的機理不甚明了,一般認為是rtb先與細胞膜受體結合,主要經過受體介導的內吞作用進入吞噬體,然后沿著內體、高爾基體、內質網等逆向分泌途徑,有序地運輸到內質網,最后從內質網轉位進入細胞漿,在胞漿內攻擊核糖體,從而抑制蛋白質的合成,導致細胞死亡。

The toxin may be formed within the pathogen and released when it dies ( endotoxin ) , or secreted through its cell wall ( exotoxin ) 在病原體內形成,當病原體裂解時被釋放的毒素為內毒素;由病原體通過細胞壁向外分泌的毒素為外毒素。

Beta - exotoxin is an inhibitor of rna polymerase and acts competitively with atp in various biological processes 外毒素是rna聚合酶的抑制劑,在各個生化過程中與atp起競爭作用。