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erk n.〔英國〕1.(英國空軍中軍階最低的)空軍兵,地勤人員...

erlanger

$ - liquid scintillation counting : erk basic activities had been found in the two control groups . the scores were 6582 . 38 ? 2605 . 70 and 6204 . 13 + 2212 . 40 . there had no obvious difference between them ( p > 0 . 05 ) . while erk activity was obviously lowered in the psd group which score was only 807 . 88 + 1326 . 76 . the expression of erk in psd group showed significant difference between the two control groups ( p < 0 . 05 ) Westernblot :快目動睡眠剝奪組jnk ( c一junnhz上erminalkinase )的表達量較兩對照組均明顯增加:與正常對照組相卜較增加了75 ;與快回動睡眠剝奪對照組相t較增加了62

Especially , at the site of implantation of day 5 , 6 , uterine stroma cell apposing the preimplantation blastocyst changed into the decidual cells and displayed a distinct immunostaining of phospho mapk . western - blot results showed p44 express stronger than p42 did , with both their peak expression were observed on day 5 , during the period of uterine decidualization 上述結果表明, ma衛k的激活與子宮內膜的接受性及蛻膜的形成有密切關系,推測mapk級聯通路激活對蛻膜化十分重要,蛻膜化可能與egf尼gfr直接或間接激活erk有關。

They are pkc , pka , mek1 in erk pathway , mekk1 in sapk / jnk , p38 in p38 pathway , the three latter pathways all belong to the map kiiiase pathway . the inhibition of pkc decreases the proliferation after the il - 16 treatments , which hint its role in proliferation signal transduction 結果表明,加入pkc的抑制劑,強烈抑制了所有濃度16處理下細胞的增殖,暗示pkc在u一16與cd4結合后,可能傳遞了增殖相關信號,它的存在是jllrk盯細胞的生長增殖必須的。

Interestingly , inhibition of p38 mapk activation ( but not erk activation ) by its inhibitors or by expression of a dominant negative mutant of p38 mapk could effectively block the chemotactic effect of ( - arrestin2 P38mapk上游激酶ask1的顯性失活突變體也可以阻斷- arrestin2對趨化的增強作用。這說明是p38mapk而不是erk信號通路與- arrestin2對趨化的增強作用相關。

Further analysis reveals that expression of ( - arrestin2 strengthened cxcr4 - mediated activation of both p38 mapk and erk and the suppression of ( - arrestin2 expression blocked the activation of two kinases 進一步的研究發現, - arrestin2可以增強cxcr4介導的erk及p38mapk的激活,但只有p38mapk的特異性抑制劑及顯性失活突變體才可以阻斷- arrestin2對趨化的增強作用。

P - liquid scintillation counting was used for analysis of erk and immunocytochemistry was used for the analysis of c - jun . all the data were analyzed with statistical treatment . the results were showed as follows : 1 分別做p液閃計數觀察erk的活性表達,做westernblot觀察jnk的表達量變化,免疫組化觀察cjun陽性信號的表達,并進行統計學處理,結果如下: 1

2 . the proapoptotic effects result from the reduction of erk , activation of jnk during treatment of bfgf and p38 also has some role in this process Bfgf作用于u2 os細胞引起的erk活性抑制和jnk長時程激活共同介導了u2 os細胞凋亡的發生, p38也在一定程度上參與了這個過程。

It is believed that erk mainly transduces growth promoting signals and the other two mainly tranduce growth inhibiting signals 現在認為erk1 2主要介導生長促進信號,而后兩條途徑主要介導生長抑制信號。

Effect of erk on 17 - estradiol - induced inhibition of vsmc proliferation in rats after vascular injury 雌二醇抑制大鼠血管損傷后平滑肌細胞增殖中的作用