x
uploads/xenograft.jpg

xenograft n.【醫學】異種移植物。

xenography

Although the deelopment of relatiely non - toxic immunosuppressie or tolerance - inducing regimens will be required to justify clinical trials using pig organs , recent adances in our understanding of the biology of xenograft rejection and zoonotic infections , and the generation of alpha1 , 3 - galactosyltransferase - deficient pigs hae moed this approach closer to clinical application 盡管用豬的器官去驗證臨床試驗需要相對無毒的免疫抑制劑或致耐的方法,但隨著近來我們對異種移植排斥生物學及動物傳染病感染的深入理解,以及1 , 3半乳糖轉移酶缺陷豬的產生,異種移植更接近臨床應用。

Although the development of relatively non - toxic immunosuppressive or tolerance - inducing regimens will be required to justify clinical trials using pig organs , recent advances in our understanding of the biology of xenograft rejection and zoonotic infections , and the generation of alpha1 , 3 - galactosyltransferase - deficient pigs have moved this approach closer to clinical application 盡管用豬的器官進行臨床試驗尚有賴于相對無毒的免疫抑制劑或致耐方法的發展,但是我們在異種移植排斥反應及豬源人畜共患病等方面生物學知識的進步,以及1 , 3半乳糖轉移酶缺陷豬的產生,已經使異種移植離臨床應用更近了一步。

On the consideration of these problems and the fact that the rat immune system is not fully developed until birth , we tried to transplant neonatal rat with human hscs to test the possibility of this xenograft model 但此實驗模型操作復雜且實驗周期長,大多數實驗室不具備利用此實驗模型的條件。有研究證明,新生大鼠免疫系統發育不完善,對異種抗原可形成免疫耐受。

The results suggested that human hscs can engraft into rat and differentiate into multilineage under certain microenvironment . thus , the human / rat xenograft model may provide a useful and convenient method for assay human hscs in vivo 新生大鼠免疫系統發育不完善,對異種抗原可形成免疫耐受,是很好的研究異種移植的實驗動物,且經濟。

Sandy feng , quickel rr , hollister - lock j , et al . prolonged xenograft survival of islet infected with small doses of adenovirus expressing ctla4ig . transplantation , 1999 , 67 ( 12 ) : 1607 周茂華,陳東明,唐軍民,等.大鼠胰島移植物制備與異種移植.中華器官移植雜志, 1998 , 19 ( 4 ) : 200

The hopkins group is conducting a clinical trial of the xenograft model in 40 patients undergoing surgery at johns hopkins for non - metastatic pancreas cancer 霍普金斯研究小組在霍普金斯醫院就診的40名非轉移性胰腺癌病人身上進行了異種移植小鼠模型的臨床試驗。

Study on in viro drug delivery and repairing large segmental infected bony defect with massive reconstituted bovine xenograft aided by calcium phosphate cement drug core 磷酸鈣骨水泥載藥核心的塊型重組合異種骨體內緩釋及修復兔長段感染性骨缺損的研究

Thus xenograft , or xenotransplantation is a sort of holy grail for transplantation , since animals would provide an endless supply of organs for transplantation 既然動物可以為移植提供無盡的來源,異種移植一直是人們夢寐以求的事。

Effects of arsenic trioxide on htert expression and tolemerase activity of human colonic carcinoma xenograft in nude mice 三氧化二砷對人結腸癌裸鼠移植瘤端粒酶活性及其催化亞單位表達的影響

Establishment and biological characteristics of nude mice xenograft tumor models of human endometrial carcinoma 人子宮內膜癌裸鼠模型的建立及其生物學特性的研究

Treatment of tibial plateau fracture with reconstructed bone xenograft plus buttress plate internal fixation 重組合異種骨加鋼板內固定治療脛骨平臺骨折

The experimental study on the xenograft of frozen - thawed human fetal ovarian tissue 凍融人胎兒卵巢組織異種移植的實驗研究